Serophene is a non-steroidal ovulation stimulator that treats infertility in women. It is the brand name of the generic drug clomiphene. Serophene is available for oral administration.
How it works
The active ingredient clomiphene citrate in Serophene interacts with tissues such as the hypothalamus, pituitary, endometrium and cervix that contain estrogen receptors. It works by resisting estrogen receptors that bind to these tissues and interrupts the renewal of intracellular estrogen receptors. When Serophene interferes with estrogen receptors in the hypothalamus which is responsible for controlling hormones in your body, the follicle stimulating hormone and luteinizing hormone are released from the hypothalamus. These hormones stimulate ovulation and therefore, restores normal menstruation.
Serophene is an ovulatory agent that is used to treat women with menstruation problems. It is prescribed for women who do not menstruate on a regular basis and are having difficulty in becoming pregnant.
The dosage of Serophene is determined according to your medical condition, drug tolerance and response to treatment. The dosage may vary from person to person. A patient should be thoroughly evaluated before this drug is prescribed to her.
It is important to follow the exact instructions given to you by your doctor.
This drug is administered in small doses at first. The recommended initial dosage is 50 mg (1 tablet) which is to be taken daily for a period of 5 days. The dose has to be increased if you do not respond to the initial dose.
If bleeding is experienced prior to treatment, the above dose should be initiated on the 5th day of the menstrual cycle. Treatment can be initiated at any time with persons who have not menstruated for a long time.
If you do not ovulate within first course of this treatment, the second time around increase the dosage up to 100 mg daily and continue for 5 days. The second course is started 30 days after the first course ends.
Side effects of Serophene may not be experienced by every person. However, a small percentage of women experience common side effects such as:
Multiple ovulation in between treatments
Tenderness in the breast
Difficulty in falling asleep
Discontinue this medication at once and seek medical attention if you experience any of the following side effects:
Allergic reaction to Serophene (hives/swelling of tongue/severe dizziness)
Symptoms of overstimulation of the ovaries
Unusual weight gain
This drug is not suitable for use under the medical conditions listed below.
Uncontrolled or untreated thyroid gland problems
Abnormal vaginal bleeding
Enlargement of ovaries
Allergy to ingredients in Serophene
Before using this drug, tell your doctor if you are pregnant or planning to become pregnant.
It is also important to inform your doctor if you are taking other medicines, have depression, endometriosis, ovarian cancer, high prolactin levels in your blood or a history of blood clots.
Go for regular medical tests while you are on this medication. It is important to monitor the condition of your body through blood tests, pregnancy tests and hormone checkups.